The current situation in Ukraine has led to severe supply chain disruptions, contributing to a sharp increase in food and commodity prices globally and the limitation of fossil fuel imports from Russia to the EU. Moreover, to end Europe's dependence on semiconductor suppliers from Asian countries, it is necessary to take immediate action of a structural nature, involving all EU Member States and all participants in regional supply markets. The overall aim of this study was to identify drivers of and barriers to building up open strategic autonomy at EU level, before recommending coordinated solutions and addressing supply chain resilience in four critical areas: food security, energy security, semiconductors and satellite communications. This research seeks to contribute to the European Parliament's future work by providing insights into how to protect the European agricultural sector, ensure energy security and the technological sovereignty of semiconductor production, and improve satellite communications.